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Article

CD36 Deficiency Inhibits Retinal Inflammation and Retinal Degeneration in Cx3cr1 Knockout Mice.

Frontiers in immunology - 1 Jan 2019

Lavalette Sophie, Conart Jean-Baptiste, Touhami Sara, Roubeix Christophe, Houssier Marianne, Augustin Sébastien, Raoul William, Combadière Christophe, Febbraio Maria, Ong Huy, Chemtob Sylvain, Sahel José-Alain, Delarasse Cécile, Guillonneau Xavier, Sennlaub Florian

Abstract excerpt

Background: CD36, a member of the class B scavenger receptor family, participates in Toll-like receptor signaling on mononuclear phagocytes (MP) and can promote sterile pathogenic inflammation. We here analyzed the effect of CD36 deficiency on retinal inflammation and photoreceptor degeneration, the hallmarks of age-related macular degeneration (AMD), that characterize Cx3cr1-/-mice. Methods: We analyzed...

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Identifiers

PMID: 31969887
DOI: 10.3389/fimmu.2019.03032
PMCID: PMC6960398

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