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Article

The Impact of Sex and Smoking Status on the Mutational Spectrum of Epidermal Growth Factor Receptor Gene in Non–small Cell Lung Cancer

1 Oct 2007

Abstract excerpt

PURPOSE: Mutation of epidermal growth factor receptor (EGFR) gene has been reported to be present in non-small cell lung cancer (NSCLC) and significantly associated with female sex and never-smoking status. In this study, we extensively investigated the impact of sex and smoking on the EGFR mutation. EXPERIMENTAL DESIGN: We examined EGFR exons 18 to 21 status in 1,467 NSCLC patients by direct sequencing to study...

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PMID: 17908966
DOI: 10.1158/1078-0432.ccr-07-0216

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