The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.

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Article

The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2005

Tokumo Masaki, Toyooka Shinichi, Kiura Katsuyuki, Shigematsu Hisayuki, Tomii Kunitoshi, Aoe Motoi, Ichimura Kouichi, Tsuda Toshihide, Yano Masaaki, Tsukuda Kazunori, Tabata Masahiro, Ueoka Hiroshi, Tanimoto Mitsune, Date Hiroshi, Gazdar Adi F, Shimizu Nobuyoshi

Abstract excerpt

PURPOSE: Recent studies reported that clinical responsiveness to gefitinib was associated with somatic mutation of epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC). Here, we investigated the relationship between EGFR mutation and clinicopathologic features. EXPERIMENTAL DESIGN: EGFR mutational status of 120 NSCLCs was determined mainly in EGFR exons 18 to 21 by direct sequence...

Topics

Adult
Aged
Amino Acid Sequence
Antineoplastic Agents
Base Sequence
Carcinoma, Non-Small-Cell Lung
DNA Mutational Analysis
DNA, Neoplasm
ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gefitinib

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Quinazolines

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 15709185

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15709185-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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