Article
Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2006
Pham DuyKhanh, Kris Mark G, Riely Gregory J, Sarkaria Inderpal S, McDonough Tiffani, Chuai Shaokun, Venkatraman Ennapadam S, Miller Vincent A, Ladanyi Marc, Pao William, Wilson Richard K, Singh Bhuvanesh, Rusch Valerie W
Abstract excerpt
PURPOSE: Lung adenocarcinomas with mutations in exons 19 and 21 of the epidermal growth factor receptor gene (EGFR) demonstrate sensitivity to gefitinib or erlotinib. Investigators have reported an association between EGFR mutations and the amount and duration of cigarette smoking, with the highest incidence of mutations seen in never smokers. METHODS: EGFR exon 19 and 21 mutation status was determined in 265...
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