Incidence of <i>EGFR</i> Exon 19 Deletions and L858R in Tumor Specimens From Men and Cigarette Smokers With Lung Adenocarcinomas

Abstract excerpt

PURPOSE: EGFR mutations underlie the sensitivity of lung cancers to erlotinib and gefitinib and can occur in any patient with this illness. Here we examine the frequency of EGFR mutations in smokers and men. METHODS: We determined the frequency of EGFR mutations and characterized their association with cigarette smoking status and male sex. RESULTS: We tested 2,142 lung adenocarcinoma specimens for the presence...