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Article

Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation

1 Oct 2007

Abstract excerpt

The interleukin (IL)-1 family members IL-1alpha, -1beta, and -18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Recently, several new IL-1 family members have been identified. To determine the role of one of these family members in the skin, transgenic mice expressing IL1F6 in basal keratinocytes...

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PMID: 17908936
DOI: 10.1084/jem.20070157

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