Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.

The EMBO journal - 21 Apr 2004

Li Allen G, Wang Donna, Feng Xin-Hua, Wang Xiao-Jing

Abstract excerpt

Transforming growth factor beta1 (TGFbeta1), a potent keratinocyte growth inhibitor, has been shown to be overexpressed in keratinocytes in certain inflammatory skin diseases and has been thought to counteract the effects of other growth factors at the site of inflammation. Surprisingly, our transgenic mice expressing wild-type TGFbeta1 in the epidermis using a keratin 5 promoter (K5.TGFbeta1(wt)) developed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basement Membrane
Share to Cytokines
Share to Inflammation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Psoriasis

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 15057277
DOI: 10.1038/sj.emboj.7600183
PMCID: PMC394237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.PMID 15057277Read ↗

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.Semantic proximity Read ↗

Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 functionSemantic proximity Read ↗

TGFβ Signaling in Photoaging and UV-Induced Skin Cancer.Semantic proximity Read ↗

Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice.Semantic proximity Read ↗

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis.Semantic proximity Read ↗

BMP1 Promotes Keloid by Inducing Fibroblast Inflammation and FibrogenesisSemantic proximity Read ↗

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2Semantic proximity Read ↗

Cutting Edge: NF-κB p65 and c-Rel Control Epidermal Development and Immune Homeostasis in the SkinSemantic proximity Read ↗

Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis.Semantic proximity Read ↗

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions.Semantic proximity Read ↗

Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopeciaSemantic proximity Read ↗

Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.