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Article

IL-1 Family Antagonists in Mouse and Human Skin Inflammation

16 Mar 2021

Abstract excerpt

Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammatory diseases. Dysregulated IL-1 family signaling is observed in a variety of skin disorders. In particular, IL-1 family cytokines have been linked to the pathogenesis of psoriasis...

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PMID: 33796114
DOI: 10.3389/fimmu.2021.652846

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