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Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

15 Oct 2012

Abstract excerpt

Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% of the world's population. Accumulating evidence has revealed that the IL-23/IL-17/IL-22 pathway is key for development of skin immunopathology. However, the role of keratinocytes and their crosstalk with immune cells at the onset of disease remains poorly understood. Here, we show that IL-36R-deficient (Il36r-/-) mice were...

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PMID: 23064362
DOI: 10.1172/jci63451

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