Article
Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis.
Journal of molecular medicine (Berlin, Germany) - 1 Jul 2021
Xu Hui, Liu Jun, Niu Mengyuan, Song Shiyu, Wei Lulu, Chen Gang, Ding Yibing, Wang Yong, Su Zhonglan, Wang Hongwei
Abstract excerpt
IL-6 has been suggested to function as an autocrine mitogen in the psoriatic epidermis. The biological activity of IL-6 relies on interactions with its receptors, including the membrane-bound IL-6 receptor (mIL-6R) and soluble IL-6 receptor (sIL-6R). Our study presents data showing that the levels of plasma IL-6 and sIL-6R were elevated in psoriatic patients. Genotyping of two single-nucleotide polymorphisms...
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