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Article

Interleukin 6: insights to its function in skin by overexpression in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1992

Turksen K, Kupper T, Degenstein L, Williams I, Fuchs E

Abstract excerpt

Interleukin 6 (IL-6) is a cytokine that mediates a wide range of inflammatory and immune responses. Its expression is elevated in inflammatory or immunodeficient diseases, including psoriasis, rheumatoid arthritis, and AIDS. To explore the role of IL-6 in skin, we utilized a human keratin 14 (K14) promoter to express IL-6 in the basal cells of stratified squamous epithelia of transgenic mice. Mice expressing the...

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Identifiers

PMID: 1375756
DOI: 10.1073/pnas.89.11.5068
PMCID: PMC49230

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