Article
Interleukin 6: insights to its function in skin by overexpression in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1992
Turksen K, Kupper T, Degenstein L, Williams I, Fuchs E
Abstract excerpt
Interleukin 6 (IL-6) is a cytokine that mediates a wide range of inflammatory and immune responses. Its expression is elevated in inflammatory or immunodeficient diseases, including psoriasis, rheumatoid arthritis, and AIDS. To explore the role of IL-6 in skin, we utilized a human keratin 14 (K14) promoter to express IL-6 in the basal cells of stratified squamous epithelia of transgenic mice. Mice expressing the...
Topics
- Animals
- Base Sequence
- Epithelium
- Gene Expression
- Inflammation
- Interleukin-6
- Keratinocytes
- Keratins
- Leukocytes
- Mice
- Mice, Transgenic
- Molecular Sequence Data