Article
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003
Apostol Barbara L, Kazantsev Alexsey, Raffioni Simona, Illes Katalin, Pallos Judit, Bodai Laszlo, Slepko Natalia, Bear James E, Gertler Frank B, Hersch Steven, Housman David E, Marsh J Lawrence, Thompson Leslie Michels
Abstract excerpt
The formation of polyglutamine-containing aggregates and inclusions are hallmarks of pathogenesis in Huntington's disease that can be recapitulated in model systems. Although the contribution of inclusions to pathogenesis is unclear, cell-based assays can be used to screen for chemical compounds that affect aggregation and may provide therapeutic benefit. We have developed inducible PC12 cell-culture models to...
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