Article
Mtbp haploinsufficiency in mice increases tumor metastasis.
Oncogene - 20 Mar 2008
Iwakuma T, Tochigi Y, Van Pelt C S, Caldwell L C, Terzian T, Parant J M, Chau G P, Koch J G, Eischen C M, Lozano G
Abstract excerpt
Mdm2 inhibits the function of the p53 tumor suppressor. Mdm2 is overexpressed in many tumors with wild-type p53 suggesting an alternate mechanism of loss of p53 activity in tumors. An Mdm2-binding protein (MTBP) was identified using a yeast two-hybrid screen. In tissue culture, MTBP inhibits Mdm2 self-ubiquitination, leading to stabilization of Mdm2 and increased degradation of p53. To address the role of MTBP in...
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