Article
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis.
Nature communications - 1 Jan 2013
Zheng Tongsen, Wang Jiabei, Zhao Yuhan, Zhang Cen, Lin Meihua, Wang Xiaowen, Yu Haiyang, Liu Lianxin, Feng Zhaohui, Hu Wenwei
Abstract excerpt
The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 can accumulate to high levels in tumours, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulation is poorly understood. Here we find that MDM2 isoforms promote mutp53 accumulation in tumours. MDM2 isoform B...
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