The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.

doi:10.1002/path.4854

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Article

The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.

The Journal of pathology - 1 Mar 2017

Xiong Shunbin, Pant Vinod, Zhang Yun, Aryal Neeraj K, You M James, Kusewitt Donna, Lozano Guillermina

Abstract excerpt

The p53 inhibitor Mdm4 is present at high levels in multiple human cancers. Overexpression of Mdm4 in mice drives the spontaneous development of mostly lymphomas and sarcomas. In this study, we explored the ability of Mdm4 to cooperate with lesions in tumour development. The Mdm4 transgene contributed to mammary tumour development in a BALB/cJ background. High levels of Mdm4 enhanced tumour development in a...

Topics

Animals
Carcinogenesis
Gene Expression Regulation, Neoplastic
Humans
Loss of Heterozygosity
Lymphoma
Male
Mice
Mice, Inbred BALB C
Mice, Knockout
Mutation
Proto-Oncogene Proteins
Sarcoma
Transgenes
Tumor Suppressor Protein p53

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Identifiers

PMID: 27925213
DOI: 10.1002/path.4854
PMCID: PMC5315583

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