Adaptive landscape of protein variation in human exomes

Abstract excerpt

The human genome contains hundreds of thousands of missense mutations. However, only a handful of these variants are known to be adaptive, which implies that adaptation through protein sequence change is an extremely rare phenomenon in human evolution. Alternatively, existing methods may lack the power to pinpoint adaptive variation. We have developed and applied an Evolutionary Probability Approach (EPA) to disco...

Topics

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• Adaptation, Biological
• Disease
• Evolution, Molecular
• Genetic Variation
• Genome
• Genomics
• Mutation
• Phylogeny

Identifiers and source

Literature Corpus work

a8f4cdbc-5195-5e1d-af2c-ee9b3dd0fd67

DOI

10.1101/282152