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Article

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.

Neurobiology of disease - 1 Jan 2008

Charvin Delphine, Roze Emmanuel, Perrin Valérie, Deyts Carole, Betuing Sandrine, Pagès Christiane, Régulier Etienne, Luthi-Carter Ruth, Brouillet Emmanuel, Déglon Nicole, Caboche Jocelyne

Abstract excerpt

Huntington's disease (HD) results from an abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This mutation causes preferential degeneration of striatal projection neurons. We previously demonstrated, in vitro, that dopaminergic D2 receptor stimulation acted synergistically with mutated huntingtin (expHtt) to increase aggregate formation and striatal death. In the present work, we...

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PMID: 17905594
DOI: 10.1016/j.nbd.2007.07.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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