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Article

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2007

Palfi Stéphane, Brouillet Emmanuel, Jarraya Béchir, Bloch Jocelyne, Jan Caroline, Shin Masahiro, Condé Françoise, Li Xiao-Jiang, Aebischer Patrick, Hantraye Philippe, Déglon Nicole

Abstract excerpt

Huntington's disease (HD) is a neurological disorder characterized by striatal degeneration, motor symptoms and complex neuropsychiatric alterations. There is currently no genetic model of HD in non-human primates (NHPs). In this study we investigated neuropathological and behavioral changes following injections of lentiviral vectors encoding a fragment of mutated huntingtin (Htt171-82Q) into the dorsolateral...

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PMID: 17505477
DOI: 10.1038/sj.mt.6300185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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