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Article

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment.

Neurobiology of disease - 1 Dec 2005

Zala Diana, Benchoua Alexandra, Brouillet Emmanuel, Perrin Valérie, Gaillard Marie-Claude, Zurn Anne D, Aebischer Patrick, Déglon Nicole

Abstract excerpt

A lentiviral vector expressing a mutant huntingtin protein (htt171-82Q) was used to generate a chronic model of Huntington's disease (HD) in rat primary striatal cultures. In this model, the majority of neurons expressed the transgene so that Western blot analysis and flow cytometry measurement c...

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Source

Identifiers

PMID: 16006135
DOI: 10.1016/j.nbd.2005.05.017

Genes

BDNF
CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16006135-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment.PMID 16006135Read ↗

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