Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease.

BMC molecular biology - 9 Oct 2008

van Roon-Mom Willeke M C, Pepers Barry A, 't Hoen Peter A C, Verwijmeren Carola A C M, den Dunnen Johan T, Dorsman Josephine C, van Ommen Gertjan B

Abstract excerpt

BACKGROUND: Huntington's disease is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD or Huntington's disease gene. Although micro array studies on patient and animal tissue provide valuable information, the primary effect of mutant hun...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Green Fluorescent Proteins
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to NF-E2-Related Factor 2

Share to Oxidative Stress

Share to PC12 Cells

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 18844975
DOI: 10.1186/1471-2199-9-84
PMCID: PMC2588454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18844975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease.PMID 18844975Read ↗

Antioxidant and Anti-Inflammatory Defenses in Huntington’s Disease: Roles of NRF2 and PGC-1α, and Therapeutic StrategiesSemantic proximity Read ↗

Antioxidant and Anti-Inflammatory Defense in Huntington’s Disease: Role of NRF2 and Pgc-1α and Therapeutic StrategiesSemantic proximity Read ↗

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.Semantic proximity Read ↗

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity Read ↗

Huntington's disease: underlying molecular mechanisms and emerging concepts.Semantic proximity Read ↗

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant responseSemantic proximity Read ↗

Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies.Semantic proximity Read ↗

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.Semantic proximity Read ↗

Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.Semantic proximity Read ↗

Curcumin modulates cell death and is protective in Huntington's disease model.Semantic proximity Read ↗

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.Semantic proximity Read ↗

Mechanistic insights on the role of Nrf-2 signalling in Huntington’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.