Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopamine D1 receptor-mediated aggregation of N-terminal fragments of mutant huntingtin and cell death in a neuroblastoma cell line.

Neuroscience - 15 May 2008

Robinson P, Lebel M, Cyr M

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by abnormal CAG repeat expansion in the IT15 gene encoding huntingtin protein (htt). Mutated htt is predicted to acquire toxic properties in specific brain regions. For instance, striatal neurons expressing dopamine receptors predominantly degenerate in HD patients. Although the basis of this specific vulnerability remains unclear, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Cytoplasm
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Inclusion Bodies

Share to Neuroblastoma

Share to Protein Transport

Share to Receptors, Dopamine D1

Source

Identifiers

PMID: 18403126
DOI: 10.1016/j.neuroscience.2008.02.052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopamine D1 receptor-mediated aggregation of N-terminal fragments of mutant huntingtin and cell death in a neuroblastoma cell line.PMID 18403126Read ↗

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.Semantic proximity Read ↗

Huntington's disease and Group I metabotropic glutamate receptors.Semantic proximity Read ↗

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell cultureSemantic proximity Read ↗

Soluble N-terminal fragment of mutant Huntingtin protein impairs mitochondrial axonal transport in cultured hippocampal neurons.Semantic proximity Read ↗

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's diseaseSemantic proximity Read ↗

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Semantic proximity Read ↗

The selective vulnerability of nerve cells in Huntington's diseaseSemantic proximity Read ↗

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.Semantic proximity Read ↗

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity.Semantic proximity Read ↗

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity.Semantic proximity Read ↗

Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington diseaseSemantic proximity Read ↗

A cellular model that recapitulates major pathogenic steps of Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.