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Article

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb.

Developmental biology - 1 Nov 2007

Nam Ju-Suk, Park Emily, Turcotte Taryn J, Palencia Servando, Zhan Xiaoming, Lee Jackie, Yun Kyuson, Funk Walter D, Yoon Jeong Kyo

Abstract excerpt

The R-spondin (Rspo) family of proteins consists of secreted cysteine-rich proteins that can activate beta-catenin signaling via the Frizzled/LRP5/6 receptor complex. Here, we report that targeted inactivation of the mouse Rspo2 gene causes developmental limb defects, especially in the hindlimb. Although the initiation of the expression of apical ectodermal ridge (AER)-specific genes, including fibroblast growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17904116
DOI: 10.1016/j.ydbio.2007.08.023
PMCID: PMC2692258

Genes

FGF4
FGF8
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb.PMID 17904116Read ↗

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