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Article

Sp8 is crucial for limb outgrowth and neuropore closure.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2003

Bell Sheila M, Schreiner Claire M, Waclaw Ronald R, Campbell Kenneth, Potter S Steven, Scott William J

Abstract excerpt

In this report we describe the developmental expression and function of Sp8, a member of the Sp family of zinc finger transcription factors, and provide evidence that the legless transgene insertional mutant is a hypomorphic allele of the Sp8 gene. Sp8 is expressed during embryogenesis in the forming apical ectodermal ridge (AER), restricted regions of the central nervous system, and tail bud. Targeted deletion...

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Identifiers

PMID: 14526104
DOI: 10.1073/pnas.2134310100
PMCID: PMC218735

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