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Article

Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2007

Arum Oge, Johnson Thomas E

Abstract excerpt

Hyperactivation of mammalian p53 has been shown to result in segmental progeria and decreased survivorship. Repression of the p53 homolog in Drosophila melanogaster has also been shown to increase survival. We show that RNA interference (RNAi) or genetic knockout of the Caenorhabditis elegans p53 ortholog, cep-1, leads to increased life span, which is dependent upon functional daf-16. Furthermore, one other DNA...

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Identifiers

PMID: 17895432
DOI: 10.1093/gerona/62.9.951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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