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Article

Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.

Cell - 11 Feb 2005

Schumacher Björn, Hanazawa Momoyo, Lee Min-Ho, Nayak Sudhir, Volkmann Katrin, Hofmann E Randal, Hofmann Randall, Hengartner Michael, Schedl Tim, Gartner Anton

Abstract excerpt

p53 is a tumor suppressor gene whose regulation is crucial to maintaining genome stability and for the apoptotic elimination of abnormal, potentially cancer-predisposing cells. C. elegans contains a primordial p53 gene, cep-1, that acts as a transcription factor necessary for DNA damage-induced apoptosis. In a genetic screen for negative regulators of CEP-1, we identified a mutation in GLD-1, a translational...

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PMID: 15707894
DOI: 10.1016/j.cell.2004.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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