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Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

15 Jul 2008

Abstract excerpt

BACKGROUND: In contrast to the three mammalian p53 family members, p53, which is generally involved in DNA damage responses, and p63 and p73 which are primarily needed for developmental regulation, cep-1 encodes for the single C. elegans p53-like gene. cep-1 acts as a transcription activator in a primordial p53 pathway that involves CEP-1 activation and the CEP-1 dependent transcriptional induction of the worm...

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PMID: 18627611
DOI: 10.1186/1471-2164-9-334

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