Article
Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie - 1 May 2010
Cotterill Lynn, Payne Debbie, Levinson Scott, McLaughlin John, Wesley Emma, Feeney Mark, Durbin Hilary, Lal Simon, Makin Alistair, Campbell Simon, Roberts Stephen A, O'Neill Catherine, Edwards Cathryn, Newman William G
Abstract excerpt
BACKGROUND/OBJECTIVE: Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn's disease (CD). Both genes were identified through genome-wide association scans and subsequent studies have validated these associations. To assess the effect size of these variants, an independent case-control association study and...
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