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Article

CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population.

Inflammatory bowel diseases - 1 May 2008

Baptista Márcia Luiza, Amarante Heda, Picheth Geraldo, Sdepanian Vera Lucia, Peterson Nicholas, Babasukumar Umesh, Lima Hermênio C, Kugathasan Subra

Abstract excerpt

BACKGROUND: Although many genetic variants are identified in association with Crohn's disease (CD), CARD15, IL23R, and ATG16L1 association with CD have been firmly confirmed in Caucasians of European ancestry. The prevalence of CD is rapidly rising in Brazil, where European ancestry is firmly admixed with natives and Africans, resulting in a heterogeneous population. We investigated the contribution of CARD15,...

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PMID: 18200510
DOI: 10.1002/ibd.20372

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