Article
Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males.
American heart journal - 1 Oct 2007
Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke
Abstract excerpt
BACKGROUND: The beta1- and beta2-adrenergic receptors (ARs) coexist in the human heart and control sympathetic responses. Several functional genetic variations in the beta-AR genes (ADRB1 or ADRB2) have been identified and implicated as causes of hypertension and cardiovascular disease. We assessed the relationship between 4 representative genetic polymorphisms of beta-AR (Ser49Gly and Arg389Gly in beta1-AR,...
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