Article
Risk factors and myocardial infarction in patients with obstructive sleep apnea: impact of beta2-adrenergic receptor polymorphisms.
BMC medicine - 1 Jan 2007
Bartels Nina K, Börgel Jan, Wieczorek Stefan, Büchner Nikolaus, Hanefeld Christoph, Bulut Daniel, Mügge Andreas, Rump Lars C, Sanner Bernd M, Epplen Jörg T
Abstract excerpt
BACKGROUND: The increased sympathetic nervous activity in patients with obstructive sleep apnea (OSA) is largely responsible for the high prevalence of arterial hypertension, and it is suggested to adversely affect triglyceride and high-density lipoprotein (HDL) cholesterol levels in these patients. The functionally relevant polymorphisms of the beta2-adrenergic receptor (Arg-47Cys/Arg16Gly and Gln27Glu) have...
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