Article
β-1 and β-2 adrenergic receptor polymorphism and association with cardiovascular response to orthostatic screening.
Autonomic neuroscience : basic & clinical - 28 Oct 2011
Wittwer E D, Liu Z, Warner N D, Schroeder D R, Nadeau A M, Allen A R, Murillo C J, Elvebak R L, Aakre B M, Eisenach J H
Abstract excerpt
Variation in the beta-1 and beta-2 adrenergic receptor genes (ADRB1 and ADRB2, respectively) may influence cardiovascular reactivity including orthostatic stress. We tested this hypothesis in a head-up tilt (HUT) screening protocol in healthy young adults without history of syncope. Following brachial arterial catheter insertion, 120 subjects (age 18-40, 72 females, Caucasian) underwent 5min 60° HUT....
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