Article
Allelotype analysis of childhood acute lymphoblastic leukemia.
Cancer research - 15 Nov 1995
Takeuchi S, Bartram C R, Wada M, Reiter A, Hatta Y, Seriu T, Lee E, Miller C W, Miyoshi I, Koeffler H P
Abstract excerpt
To identify the genetic events that may play an important role in leukemogenesis of childhood ALL, we report for the first time the allelotyping of childhood ALL. Twenty-four cases of childhood ALL were screened for loss of heterozygosity (LOH) using 101 highly polymorphic microsatellite markers, which are distributed among all autosomal chromosomes. For LOH analysis on both chromosomes 9 and 12, 54 childhood ALL...
Topics
- Adolescent
- Alleles
- Carrier Proteins
- Cell Cycle Proteins
- Child
- Child, Preschool
- Chromosome Deletion
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Female
- Humans