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Article

CCR5Δ32 - A piece of protection in the inflammatory puzzle of multiple sclerosis susceptibility.

Human immunology - 1 Aug 2018

Troncoso Lian Lopes, Pontillo Alessandra, Oliveira Enedina Maria Lobato de, Finkelszteijn Alessandro, Schneider Silvete, Chies José Artur Bogo

Abstract excerpt

BACKGROUND: Leucocyte infiltration and activation in the central nervous system (CNS) is an important step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5) is implicated in immune cell migration and cytokine release in the CNS, and it was demonstrated to strongly contribute to CNS inflammation and damage in several models of sterile and pathogen-mediated CNS diseases. Although the...

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Source

Identifiers

PMID: 29729320
DOI: 10.1016/j.humimm.2018.04.015

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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