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Article

CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis.

Journal of neuroimmunology - 1 Dec 2005

Kantarci Orhun H, Morales Yazmín, Ziemer Patricia A, Hebrink David D, Mahad Don J, Atkinson Elizabeth J, Achenbach Sara J, De Andrade Mariza, Mack Matthias, Ransohoff Richard M, Lassmann Hans, Bruck Wolfgang, Weinshenker Brian G, Lucchinetti Claudia F

Abstract excerpt

Four distinct patterns of tissue injury have been described in multiple sclerosis (MS) lesions. Infiltrating monocytes in lesions of all patterns co-express CCR1 and CCR5. However, in pattern II lesions, the number of CCR1 cells is decreased, while the number of CCR5 expressing cells is increased in late active versus early active regions. In contrast, CCR1 and CCR5 cells were equal in all regions of pattern III...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16182378
DOI: 10.1016/j.jneuroim.2005.07.025

Genes

CCR5
CCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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