Article
Failure to establish linkage on the X chromosome in 301 families with schizophrenia or schizoaffective disorder.
American journal of medical genetics - 12 Jun 2000
DeLisi L E, Shaw S, Sherrington R, Nanthakumar B, Shields G, Smith A B, Wellman N, Larach V W, Loftus J, Razi K, Stewart J, Comazzi M, Vita A, De Hert M, Crow T J
Abstract excerpt
The hypothesis that a gene for susceptibility to psychosis (specifically in the X-Y homologous class) is located on the sex chromosomes has been proposed. Such a gene would account for the excess of sex chromosome anomalous males and females in populations of patients with psychosis, a tendency towards concordance by sex within families, and sex differences associated with psychosis and its underlying brain...
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