Article
Maternal transmission of multiple sclerosis in a dutch population.
Archives of neurology - 1 Mar 2008
Hoppenbrouwers Ilse A, Liu Fan, Aulchenko Yurii S, Ebers George C, Oostra Ben A, van Duijn Cornelia M, Hintzen Rogier Q
Abstract excerpt
OBJECTIVE: To investigate the parental relationship of patients with multiple sclerosis (MS) from an extended pedigree with extensive genealogical information up to the middle of the 18th century. DESIGN: Multiple sclerosis is a complex disease resulting from genetic and environmental factors. Parent-of-origin effect, a phenomenon when the same allele may express differently depending on the sex of the...
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