Article
Autism and the X chromosome. Multipoint sib-pair analysis.
Archives of general psychiatry - 1 Nov 1996
Hallmayer J, Hebert J M, Spiker D, Lotspeich L, McMahon W M, Petersen P B, Nicholas P, Pingree C, Lin A A, Cavalli-Sforza L L, Risch N, Ciaranello R D
Abstract excerpt
BACKGROUND: Genetic factors undoubtedly play a major etiologic role in autism, but how it is inherited remains unanswered. The increased incidence in males suggests possible involvement of the X chromosome. METHODS: Using data from 38 multiplex families with autism (2 or more autistic siblings), we performed a multipoint sib-pair linkage analysis between autism and 35 microsatellite markers located on the X...
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