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Article

Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression.

Physiological genomics - 19 Dec 2007

Mansergh Fiona C, Wells Timothy, Elford Carole, Evans Samuel L, Perry Mark J, Evans Martin J, Evans Bronwen A J

Abstract excerpt

Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low-turnover osteopenia in the 129Sv/C57BL/6 exon 4 knockout. Since both Sparc null mutations result in complete absence of Sparc protein, similar phenotypic outcomes are...

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Identifiers

PMID: 17878319
DOI: 10.1152/physiolgenomics.00151.2007
PMCID: PMC2323447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878319-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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