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Article

Osteonectin-null mutation compromises osteoblast formation, maturation, and survival.

Endocrinology - 1 Jun 2003

Delany Anne M, Kalajzic Ivo, Bradshaw Amy D, Sage E Helene, Canalis Ernesto

Abstract excerpt

Osteonectin, also known as SPARC (secreted protein acidic and rich in cysteine) or BM-40, is one of the most abundant noncollagenous proteins in bone. Analysis of osteonectin-null mice revealed that osteonectin is necessary for the maintenance of bone mass and normal remodeling, as osteonectin-null mice have decreased osteoblast number and bone formation rate. Cultures of bone marrow stromal cells and osteoblasts...

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Source

Identifiers

PMID: 12746322
DOI: 10.1210/en.2002-221044

Genes

PTH
SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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