Article
SPARC/osteonectin in mineralized tissue.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2000
Rosset Emilie M, Bradshaw Amy D
Abstract excerpt
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues. This review will focus on elucidating functional roles of SPARC in bone formation building upon results from non-mineralized cells and tissues, the phenotype of SPARC-null bones, and recent discoveries of human diseases with either dysregulated expression of...
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