Article
A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2015
Dole Neha S, Kapinas Kristina, Kessler Catherine B, Yee Siu-Pok, Adams Douglas J, Pereira Renata C, Delany Anne M
Abstract excerpt
Osteonectin/SPARC is one of the most abundant noncollagenous extracellular matrix proteins in bone, regulating collagen fiber assembly and promoting osteoblast differentiation. Osteonectin-null and haploinsufficient mice have low-turnover osteopenia, indicating that osteonectin contributes to normal bone formation. In male idiopathic osteoporosis patients, osteonectin 3' untranslated region (UTR)...
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