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Article

Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes.

PloS one - 1 Jan 2014

Li Qiaoli, Guo Haitao, Chou David W, Berndt Annerose, Sundberg John P, Uitto Jouni

Abstract excerpt

Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(-/-) ) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and progressive mineralization of vibrissae dermal sheath, which serves as a biomarker of the overall mineralization process. Recently, as part of a mouse aging study...

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Identifiers

PMID: 24586646
DOI: 10.1371/journal.pone.0089268
PMCID: PMC3929712

Genes

ABCC6

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