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Article

Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.

Journal of cellular physiology - 1 Jan 2018

Liron Tamar, Raphael Bitya, Hiram-Bab Sahar, Bab Itai A, Gabet Yankel

Abstract excerpt

The inbred mouse strain C57BL/6 is commonly used for the generation of transgenic mouse and is a well established strain in bone research. Different vendors supply different substrains of C57BL/6J as wild-type animals when genetic drift did not incur any noticeable phenotype. However, we sporadically observed drastic differences in the bone phenotype of "WT" C57BL/6J mice originating from different labs and...

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PMID: 28266709
DOI: 10.1002/jcp.25895

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