Article
Evaluation of the interleukin-23 receptor gene coding variant R381Q in pediatric and adult Crohn disease.
Journal of pediatric gastroenterology and nutrition - 1 Oct 2007
Leshinsky-Silver Esther, Karban Amir, Dalal Ilan, Eliakim Rami, Shirin Haim, Tzofi Tzipi, Boaz Mona, Levine Arie
Abstract excerpt
BACKGROUND: Pediatric-onset Crohn disease (CD) may differ in genotype or phenotype from adult-onset CD. Genome-wide screening recently identified a protective mutation (R381Q) in the interleukin-23 (IL-23) receptor gene located on chromosome 1. The aims of our study were to evaluate whether this mutation is associated with CD in our population and to find whether it may have an impact on age of onset or a...
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