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Article

Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics.

Journal of biological rhythms - 1 Oct 2007

Reischl Silke, Vanselow Katja, Westermark Pål O, Thierfelder Nadine, Maier Bert, Herzel Hanspeter, Kramer Achim

Abstract excerpt

Regulated degradation of circadian clock proteins is a crucial step for rhythm generation per se but also for establishing a normal circadian period. Here, the authors show that the F-box protein beta-transducin repeat containing protein 1 (beta-TrCP1) as part of the E3 ubiquitin ligase complex is an essential component of the mammalian circadian oscillator. Down-regulation of endogenous beta-TrCP1 as well as...

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Source

Identifiers

PMID: 17876059
DOI: 10.1177/0748730407303926

Genes

PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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