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Article

Dmbx1 is essential in agouti-related protein action.

Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2007

Fujimoto Wakako, Shiuchi Tetsuya, Miki Takashi, Minokoshi Yasuhiko, Takahashi Yoshihisa, Takeuchi Ayako, Kimura Kazuhiro, Saito Masayuki, Iwanaga Toshihiko, Seino Susumu

Abstract excerpt

Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1(-/-) mouse from its cohabitants induces self-starvation, sometimes leading to death, features similar to those of anorexia nervosa in humans. Interestingly, overexpression of agouti in Dmbx1(-/-) mice failed to induce...

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Identifiers

PMID: 17873059
DOI: 10.1073/pnas.0707328104
PMCID: PMC1976593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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