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Article

Agouti/melanocortin interactions with leptin pathways in obesity.

Nutrition reviews - 1 Sept 1998

Zemel M B

Abstract excerpt

The cloning of mouse obesity genes and their human homologues provides unique opportunities to identify novel cellular targets for therapeutic intervention. The first of these to be cloned, agouti, antagonizes central nervous system melanocortin receptor (MCR) binding, resulting in hyperphagia an...

Topics

Agouti Signaling Protein
Animals
Humans
Intercellular Signaling Peptides and Proteins
Leptin
Mice
Mutation
Obesity
Proteins
Receptors, Corticotropin
Receptors, Leptin
Receptors, Melanocortin
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9763877
DOI: 10.1111/j.1753-4887.1998.tb01764.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9763877-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Agouti/melanocortin interactions with leptin pathways in obesity.PMID 9763877Read ↗

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Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.Semantic proximity Read ↗

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.Semantic proximity Read ↗

Pro-opiomelanocortin and weight regulation: from mice to men.Semantic proximity Read ↗

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Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.Semantic proximity Read ↗

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