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Article

Agouti/melanocortin interactions with leptin pathways in obesity.

Nutrition reviews - 1 Sept 1998

Zemel M B

Abstract excerpt

The cloning of mouse obesity genes and their human homologues provides unique opportunities to identify novel cellular targets for therapeutic intervention. The first of these to be cloned, agouti, antagonizes central nervous system melanocortin receptor (MCR) binding, resulting in hyperphagia and an obesity/hyperinsulinemia syndrome. There appears to be significant cross-talk between the agouti and leptin...

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Source

Identifiers

PMID: 9763877
DOI: 10.1111/j.1753-4887.1998.tb01764.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Agouti/melanocortin interactions with leptin pathways in obesity.PMID 9763877Read ↗

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Melanocortin-4 receptor: a novel signalling pathway involved in body weight regulation.Semantic proximity Read ↗

Agouti Expression in Human Adipose TissueSemantic proximity Read ↗

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related ProteinSemantic proximity Read ↗

Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.Semantic proximity Read ↗

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.Semantic proximity Read ↗

Pro-opiomelanocortin and weight regulation: from mice to men.Semantic proximity Read ↗

Mouse models of obesity.Semantic proximity Read ↗

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.Semantic proximity Read ↗

Creation of a genetic model of obesity in a teleostSemantic proximity Read ↗

The role of the Agouti-Related Protein in energy balance regulation.Semantic proximity Read ↗

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