Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

doi:10.1101/gad.11.5.593

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Article

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

Genes & development - 1 Mar 1997

Shutter J R, Graham M, Kinsey A C, Scully S, Lüthy R, Stark K L

Abstract excerpt

We have isolated cDNA clones that encode a novel human gene related to agouti. Sequence analysis of this gene, named ART, for agouti-related transcript, predicts a 132-amino-acid protein that is 25% identical to human agouti. The highest degree of identity is within the carboxyl terminus of both...

Topics

Agouti Signaling Protein
Agouti-Related Protein
Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Calcium
Chromosome Mapping
Chromosomes, Human, Pair 16
Cloning, Molecular
Conserved Sequence
Databases, Factual
Diabetes Mellitus, Experimental
Disease Models, Animal
Humans
Hypothalamus
Intercellular Signaling Peptides and Proteins

Source

Open in PubMed

Identifiers

PMID: 9119224
DOI: 10.1101/gad.11.5.593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9119224-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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