Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever.

Genes and immunity - 1 Dec 2007

Everett B, Cameron B, Li H, Vollmer-Conna U, Davenport T, Hickie I, Wakefield D, Vernon S, Reeves W C, Lloyd A R

Abstract excerpt

Coxiella burnetii is a macrophage-tropic, Gram-negative organism, which causes acute Q fever infection in humans. This zoonotic infection causes illness ranging from asymptomatic seroconversion to severe and protracted disease featuring hepatitis and pneumonia. Interactions between C. burnetii lipopolysaccharide (LPS) and host Toll-like receptors (TLR)-2 and -4 have been implicated in pathogen recognition,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity

Share to Polymorphism, Genetic

Share to Q Fever

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 17855803
DOI: 10.1038/sj.gene.6364428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever.PMID 17855803Read ↗

Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro.Semantic proximity Read ↗

Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever.Semantic proximity Read ↗

The importance of Toll-like receptor 2 polymorphisms in severe infections.Semantic proximity Read ↗

[Polymorphisms of the Toll-like receptor 4 gene and their potential role in infectious diseases and chronic inflammatory disorders].Semantic proximity Read ↗

A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.Semantic proximity Read ↗

Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q feverSemantic proximity Read ↗

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.Semantic proximity Read ↗

Functional polymorphisms in LPS receptors CD14 and TLR4 are not associated with disease susceptibility or Campylobacter jejuni infection in Guillain-Barré patients.Semantic proximity Read ↗

No associations established between single nucleotide polymorphisms in human Toll-like receptor 2 and Toll-interacting protein and Staphylococcus aureus bloodstream infections.Semantic proximity Read ↗

The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis.Semantic proximity Read ↗

Very low frequencies of Toll-like receptor 2 supposed-2029T and 2258A (RS5743708) mutant alleles in southern Brazilian critically ill patients: would it be a lack of worldwide-accepted clinical applications of Toll-like receptor 2 variants?Semantic proximity Read ↗

Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.