Article
Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro.
Cytokine - 1 Jan 2016
Ammerdorffer Anne, Stappers Mark H T, Oosting Marije, Schoffelen Teske, Hagenaars Julia C J P, Bleeker-Rovers Chantal P, Wegdam-Blans Marjolijn C, Wever Peter C, Roest Hendrik-Jan, van de Vosse Esther, Netea Mihai G, Sprong Tom, Joosten Leo A B
Abstract excerpt
Coxiella burnetii, the causative agent of Q fever, is recognized by TLR2. TLR10 can act as an inhibitory receptor on TLR2-derived immune responses. Therefore, we investigated the role of TLR10 on C. burnetii-induced cytokine production and assessed whether genetic polymorphisms in TLR10 influences the development of chronic Q fever. HEK293 cells, transfected with TLR2, TLR10 or TLR2/TLR10, and human peripheral...
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